|
Puumanen K (1), Kellomäki M (2), Ritsilä V (3),
Böhling T (4),
Törmälä P (2), Waris T (5), Ashammakhi N (6).
1. Department of Surgery, University of Helsinki, Helsinki;
2. Institute of Biomaterials, Tampere University of Technology, Tampere;
3. ORTON Research Institute, The Invalid Foundation of Helsinki, Helsinki;
4. Department of Pathology, Hartman Institute, University of Helsinki
and Helsinki University Central Hospital, Helsinki;
5. Division of Plastic Surgery, Department of Surgery, Tampere University
Hospital, Tampere;
6. Division of Plastic Surgery, Department of Surgery, Oulu University
Hospital, Oulu; Finland.
Corresponding
author:
K. Puumanen, M.D. Eskolantie 9 B 1 00720 Helsinki FINLAND Tel. + 358 9
22 33 979 Fax + 358 9 351 33 58 E mail: katja.puumanen@fimnet.fi
ABSTRACT
A new bioabsorbable composite
membrane of polyethylene oxide terephtalate and polybutylene terephtalate
(Polyactive®
70/30) combined with bioactive glass n:o 13-93 was tested in repair of
experimental maxillary alveolar cleft defects. The possible ability of
the membrane to promote bone formation by guided tissue regeneration was
investigated. A standard alveolar defect was made bilaterally in the maxilla
and filled with autogenous bone grafts in 12 growing rabbits. The test
defect was covered with the composite membrane and the other one was left
uncovered to serve as control. Follow-up was 10 weeks. Histological and
radiological evaluations and histomorphometric measurements were performed.
The results were statistically analysed. In histological evaluation the
composite membrane was found to have a local enhancing effect on osteogenic
activity at the membrane - bone interface. In histomorphometry promotion
of bone formation by the composite membrane was not observed in this pilot
series.
KEYWORDS
experimental maxillary cleft, bone grafting, bone healing, GTR, bioabsorbable
membrane, bioactive glass
|
