EDCMET

EDCMET

Currently, there are no validated methods to assess the metabolic effects of Endocrine Disruptors (EDs). To address this unmet need and other gaps in the context of ED testing, the European Union has funded eight projects on the overarching topic ‘New testing and screening methods to identify endocrine disrupting chemicals’ within the Horizon 2020 framework. One of these projects is EDCMET.

Rahoittajat

Projektin tiedot

Projektin kesto

-

Rahoittaja

Horisontti 2020

Projektin koordinaattori

University of Eastern Finland

Projektin kuvaus

EDCMET - ‘Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways’. The objective of the project is to develop validated in silico, in vitro and in vivo methods assessing metabolic effects of EDs, with a focus on energy and fat metabolism and nuclear receptors regulating these processes. Thorough understanding of the mechanisms leading to adverse metabolic effects of EDs is presently lacking.



EDCMET will apply the adverse outcome pathway (AOP) paradigm to identify molecular initiating events and predict the emergent adverse biological phenotype. The project brings together scientists with different expertise to meet the common goal to improve the currently available testing methods. EDCMET utilizes a wide variety of methodologies, ranging from computational methods, cell culture systems and up-to-date animal models, to epidemiological data, in order to associate the exposure to chemicals to ED-related metabolic effects.



UOulu group consists of three researcher groups, Prof. Jukka Hakkola, Prof. Arja Rautio and Prof. Marjo-Riitta Järvelin, from the Faculty of Medicine.

For more information about EDCMET project, please visit the EDCMET website.

Projektin tulokset

  1. Palaniswamy S, Nevala L, Pesonen P, Rautio A, Järvelin M-R, Abass K, Charles D. Environmental contaminants in Arctic human populations: Trends over 30 years. Environment International 189 (2024) 108777. https://doi.org/10.1016/j.envint.2024.108777.

  2. Palaniswamy S, Abass K, Rysa J, Grimalt J, Odland JO, Rautio A, Jarvelin M-R. Investigating the relationship between non-occupational pesticide exposure and metabolomic biomarkers. Front Public Health. 2023; 11: 1248609. doi: 10.3389/fpubh.2023.1248609

  3. Abass KM, Unguryanu T, Junqué E, Mazej D, Snoj Tratnik J, Horvat M, Grimalt J, Myllynen P, Rautio A. Pilot study on the concentrations of organochlorine compounds and potentially toxic elements in pregnant women and local food items from the Finnish Lapland. Environmental Research 211 (2022) 113122, https://doi.org/10.1016/j.envres.2022.113122.

  4. Palaniswamy S, Abass K, Rysa J, Grimalt J, Odland JO, Rautio A, Jarvelin M-R. Non-occupational exposure to pesticides and health markers in general population in Northern Finland: Differences between sexes. Environ Int https://doi.org/10.1016/j.envint.2021.106766, 2021.

  5. Xu S, Hansen S, Rautio A, Jarvelin M-R, Abass K, Rysä J, Palaniswamy S, Huber S, Grimalt JO, Dumas P, Odland JO.Monitoring temporal trends of dioxins, organochlorine pesticides and chlorinated paraffins in pooled serum samples of pregnant, postpartum and non-pregnant women from Northern Norway: The MISA Studies. Environmental Research. 204 (2022) 111980. https://doi.org/10.1016/j.envres.2021.111980.

  6. Audouze K, Zgheib E, Abass K, Baig A, Forner-Piquer I, Holbech H, Knapen D, Leonards PEG, Palasniwamy S, Rautio A, Sapounidou M, Martin OV. Evidence-based approaches to support the development of endocrine-mediated Adverse Outcome Pathways: Challenges and Opportunities. Frontiers in Toxicology, Dec 2021, vol 3, article 787017. https://doi.org/10.3389/ftox.2021.787017.

  7. Kublbeck J, Vuorio T, Niskanen J, Fortino V, Braeuning A, Abass A, Rautio A, Hakkola J, Honkakoski P, Levonen A-L. The EDCMET project: metabolic effects of endocrine disruptors. Project report. International J Mol Sciences 2020, 21, 3021; doi:10.3390/ijms21083021.

Tutkimusryhmät

Arctic Health