Beyond hypoxia-inducible factors: New Molecules Interacting in Hypoxia-Signaling and Metabolism
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Project duration
-
Project funder
Project coordinator
University of Oulu
Unit and faculty
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Project leader
- Professor; Doctoral Degree Programme Director
Project description
Hypoxia-inducible transcription factors (HIFs) contribute to these processes and our work on oxygen signaling and metabolism has revealed mechanistic details on how HIFs respond not only to hypoxia but also to reactive oxygen species (ROS) and several “non-oxygen” signals such as insulin, or cytokines generated by various enzymes in different cellular compartments. While HIFs have been extensively studied as key mediators of the hypoxic response, a myriad of additional molecules appear to actively participate in hypoxia signaling and metabolic adaptations beyond HIFs. However, whether, and how, these molecules integrate into the above mentioned mechanisms is as yet unknown. This will be clarified in the present project. From non-coding RNAs and epigenetic modifiers to novel proteins and metabolic regulators, we delve into the diverse landscape of molecules influencing hypoxia-induced pathways. Furthermore, we explore the intricate crosstalk between these emerging players, shedding light on their interplay within the intricate network governing cellular responses to low oxygen environments. As we unravel the complexities of hypoxia signaling, these insights offer promising avenues for the development of targeted therapeutic strategies in various pathological conditions associated with oxygen deprivation.
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