Sara Cruz

My phd consisted in unveiling the role of the collagen binding a1- and a2-integrins in the prostate cancer progression. We found that the dual loss of these integrins leads to a worse prognosis by activating EMT through TGFb activation. Also, we discovered that Tead1, an transcription factor, is regulating the expression of these two integrins. In conclusion, the mutual loss of ITGA1/ITGA2/TEAD1 could be a biomarker for aggressive prostate cancer.