Discovery on somatic-germline interplay implicating prostate cancer predisposition and progression
Thesis event information
Date and time of the thesis defence
Place of the thesis defence
Auditorium F101 of the Faculty of Biochemistry and Molecular Medicine (Aapistie 7B). Remote access: https://oulu.zoom.us/s/67225616630
Topic of the dissertation
Discovery on somatic-germline interplay implicating prostate cancer predisposition and progression
Doctoral candidate
Master of Science Nikolaos Giannareas
Faculty and unit
University of Oulu Graduate School, Faculty of Biochemistry and Molecular Medicine, FBMM
Subject of study
Prostate cancer, molecular biology genomics
Opponent
Adj.prof Leena Latonen, University of Eastern Finland
Custos
Proffesor Aki Manninen, University of Oulu
Description of the interaction between two transcription factors and their effect on prostate cancer progression.
We identified the relationship of possible SNPs that correlate with HNF1B expression. HNF1B expression is elevated when somatic mutation of ERG (TMPRSS2-ERG) takes place in prostate cancer . HNF1B and TMPRSS2-ERG interact together and co-occupy binding sites in locus of FAM57A which can elevate its expression and progress prostate cancer.
Last updated: 1.3.2023