Comprehensive super-enhancer analysis reveals 3D genome regulation and clinical implications at the 2q31 prostate cancer susceptibility locus

Dysregulation of distant cis-regulatory elements (CREs) is increasingly recognized as a critical driver in the initiation and progression of prostate cancer (PCa). Among these elements, super-enhancers (SEs), which are highly active distal CREs, have been shown to be essential for driving key oncogenes across various cancer types. However, despite their importance, the precise functional mechanisms of most tumour-specific SEs are still poorly understood. In this study, I present a comprehensive functional analysis of a novel SE at the 2q31 locus, which I identify as significantly associated with PCa susceptibility.